The largest reservation in the U.S. has one of the nation's highest poverty rates — more than 40 percent — and very little water infrastructure. Many residents pay nearly 50 times the municipal cost for water, which instead is delivered from a tank in the back of a truck, often resulting in water-borne intestinal illnesses.

An estimated 10 to 40 percent of prescription and over-the-counter medicines are not used, but how to properly dispose of these drugs depends on who you ask. Since there is no continuous national program, states — and even some cites — are instituting their own regulations, but not without complaints from the pharmaceutical industry.